CNBP ongoing trials

1. Preterm Care Study

SickKids Hospital, CHU Sainte-Justine Hospital and BC Children’s Hospital

Overall objectives
This is a prospective, longitudinal study in which magnetic resonance imaging (MRI) data and neurodevelopmental data will be acquired. The objectives of this study are to:

1. Analyse the effect of various clinical care techniques in the NICU on neonatal brain development as measured by MR scans acquired shortly after birth and again at term-equivalent age in newborns delivered at 24-32 weeks of gestation.

2. Determine whether specific therapy techniques are detrimental to cognitive and motor outcomes in preterm neonates (measured at 18 and 36 months of age).

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2 – Bedside monitoring of pre- and postoperative brain health in neonatal d-transposition of the great arteries

Dr. Mathieu Dehaes and The Canadian Neonatal Brain Platform

Overall objectives

 1. To characterize preoperative brain metabolic demand in neonates with CHD undergoing cardiac surgery for TGA by comparing measures of CMRO2i to age-matched healthy controls.

2. To assess causality between neonatal CMRO2i alterations and brain abnormality/injury on foetal, pre- and postoperative MRIs, with quantitative measures of brain volume, microstructure (water diffusion and fractional anisotropy), and metabolism (spectroscopic N-acetylaspartate/choline ratio).

3. To assess causality between 12-month neurodevelopmental outcome on the Bayley Scales of Infant and Toddler Development III39 and neonatal CMRO2i alterations.